Journal of the American Chemical Society

A new mechanism involving cyclic tautomers for the reaction with nucleophiles of the water-soluble peptide coupling reagent 1-ethyl-3-(3'-(dimethylamino) propyl) …

A Williams, IT Ibrahim

文献索引：Williams,A.; Ibrahim,I.T. Journal of the American Chemical Society, 1981 , vol. 103, p. 7090

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被引用次数: 80

摘要

Abstract: Rate constants for the hydrolysis of the water-soluble peptide coupling reagent l- ethyl-3-(3-(dimethylamino)-propy1) carbodiimide (EDC) exhibit a pH dependence including an acid plateau region with pKapparent= 3.2, a basic plateau from pH 6 to pH 10, and a dependence on hydroxide ion concentration from pH 11 to pH 14. Potentiometric titration shows two ionizations of pK= 3.1 and 11.1. The pH dependence of the rate constant for ...