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Investigation of the antitumor activity of new epoxide derivatives. Part II: N-glycidylated oxo-nitrogen heterocycles.

H Fischer, H Moeller, M Budnowski, G Atassi…

文献索引:Fischer; Moller; Budnowski; et al. Arzneimittel-Forschung/Drug Research, 1984 , vol. 34, # 6 p. 663 - 668

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被引用次数: 13

摘要

A number of N-glycidyl compounds derived from oxo-substituted nitrogen heterocycles such as diazines, triazines, diazoles, triazoles as well as condensed ring systems containing these units have been synthesised. All products were tested for their antitumor activity against leukaemia in the mouse. Almost all of the approx. 50 di-and triglycidyl compounds showed activity, whereby 5 of them exhibited an increase of lifespan of 200% and more. ...