Journal of heterocyclic chemistry

Synthesis of [1] benzothieno [3, 2??d] pyrimidines substituted with electron donating substituents on the benzene ring

AJ Bridges, H Zhou

文献索引：Bridges, Alexander J.; Zhou, Hairong Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1163 - 1172

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被引用次数: 21

摘要

Abstract Various 2-fluorobenzonitriles were converted to the corresponding 3-amino [1] benzothiophenecarboxylic acid esters, which in turn were annulated with formamidine or various equivalents to produce the desired tricyclic benzothienopyrimidines. Various methoxy and nitro/amino substituents were placed on the phenyl ring, requiring several different strategies to prepare the desired benzothiophenes. Several different pyrimidone ...