Asymmetric Synthesis of 1-Benzyltetrahydroisoquinolines Using Chiral Oxazolo (2, 3-a) tetrahydroisoquinolines.

橋垣国子， 管慶三， /竹内靖雄， 大和正利…

文献索引：Chemical and Pharmaceutical Bulletin, , vol. 39, # 5 p. 1126 - 1131

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被引用次数: 18

摘要

... R'=CH2Ar 8 (S)-1 —> + \ 2h 1) separation 7 \ mNOH 2) H2, Pd-C I// _NH R CHzAr CHzAr 9 00-1 Chart 1 © 1991 Pharmaceutical Society of ... by flash chromatography on silica gel (hexane:AcOEt= 1 : l) to give a mixture of 8e—i and 9e—i in the combined chemical yield as ... IR ...