Tetrahedron Letters

Intramolecular N-arylation in heterocyclization: synthesis of new pyrido-fused pyrrolo [1, 2-a][1, 4] diazepinones

L Legerén, D Domínguez

文献索引：Legeren, Loreto; Dominguez, Domingo Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4053 - 4057

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被引用次数: 8

摘要

Alkylation of l-prolinamide with 3-(chloromethyl)-2-halopyridines, followed by cyclization through an intramolecular Pd-catalysed amidation, provided an entry to the pyrido [2, 3-e] pyrrolo [1, 2-a][1, 4] diazepin-10-one scaffold. Furthermore, a synthetic route towards diverse new pyrido [f] pyrrolo [1, 2-a][1, 4] diazepin-7-ones has been developed by acylation of contiguously substituted (aminomethyl) halopyridines with Boc-l-proline followed by ...