A reappraisal of the effect upon thymidine kinase of thymidine derivatives carrying large groups at the 5'-position

…, LC Davies, JA Stock, KR Harrap

文献索引：Barrie; Davies; Stock; Harrap Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1044 - 1047

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被引用次数: 8

摘要

Several thymidine derivatives with hydrophobic 5'-substituents, linked by chemically stable amide and ether links, were synthesized as potential thymidine kinase inhibitors. None of these was active nor were several derivatives of thymidine 5'-acetate, which were previously reported to be inhibitors. It was shown that the apparent inhibition by the latter compounds was due to their facile hydrolysis in aqueous solution with release of thymidine. These ...