12-Helix formation in aqueous solution with short β-peptides containing pyrrolidine-based residues

X Wang, JF Espinosa, SH Gellman

文献索引：Wang, Xifang; Espinosa, Juan F.; Gellman, Samuel H. Journal of the American Chemical Society, 2000 , vol. 122, # 19 p. 4821 - 4822

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被引用次数: 159

摘要

Oligomers that display well-defined and predictable conformations (“foldamers”) have become subjects of widespread interest in recent years. 1, 2 The foldamer strategy could be useful for creating specific molecular shapes or specific arrangements of functional groups, as required for many design goals. The traditional approach to controlling shape and surface functionality involves small, rigid skeletons, which are usually nonperiodic. In ...