Process development of a potent bradykinin 1 antagonist

…, TD Nelson, MH Kress, DE Frantz

文献索引：DiMichele, Lisa; Menzel, Karsten; Mills, Paul; Frantz, Doug; Nelson, Todd Magnetic Resonance in Chemistry, 2006 , vol. 44, # 11 p. 1041 - 1043

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被引用次数: 25

摘要

As part of Merck's continued research effort on inflammation and pain, a safe synthesis of an orally bioavailable and CNS penetrant bradykinin 1 antagonist was developed and demonstrated on kilogram scale. The key step included a novel regioselective metal−