Bioorganic & medicinal chemistry

Synthesis of 2-[6-(2, 4-Dinitrophenoxy) hexyl] oxiranecarboxylic acid: A selective carnitine palmitoyltransferase-1 inhibitor

TL Hutchison, WJ Brouillette

文献索引：Hutchison, Tracy L.; Brouillette, Wayne J. Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 11 p. 2133 - 2138

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被引用次数: 4

摘要

Carnitine palmitoyltransferases 1 and 2 (CPT-1 and CPT-2) catalyze the transfer of long chain fatty acids between carnitine and coenzyme A. Unlike CPT-2, CPT-1 exists in at least two isoforms with different physical and kinetic properties. Liver and skeletal muscle each contain a different isoform of CPT-1. Cardiac muscle contains both isoforms, and the minor component is identical to the isoform found in the liver. 2-[6-(2, 4-Dinitrophenoxy) hexyl] ...