We have an ongoing interest in the chemistry of modified amino acids, in particular N-methyl α-amino acids [1–5] and β-amino acids.[6–9] Methodological developments in this area are continuing. In the next phase of our project, we are seeking to apply N-methyl amino acids in the synthesis of target peptides including some of the growing number of naturally occurring cyclic depsipeptides found to have antifungal activity. Accordingly, our attention was ...
