The Journal of Organic Chemistry

Efficient total syntheses of the oligopeptide antibiotics netropsin and distamycin

JW Lown, K Krowicki

文献索引：Lown, J. William; Krowicki, Krzysztof Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3774 - 3779

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被引用次数: 106

摘要

New and efficient total syntheses of the natural oligopeptide antiviral antibiotics netropsin and distamycin are described. These procedures feature a different strategy of introduction of the terminal groups from that used hitherto, high yield coupling steps, improvements in the Pinner reaction for introducing the amidine moiety, and the novel use of N-formylimidazole for introduction of the formyl moiety in distamycin. The methods also avoid column ...