Nature Chemistry

Chemoselective synthesis of ketones and ketimines by addition of organometallic reagents to secondary amides

WS Bechara, G Pelletier, AB Charette

文献索引：Bechara, William S.; Pelletier, Guillaume; Charette, Andre B. Nature Chemistry, 2012 , vol. 4, # 3 p. 228 - 234

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被引用次数: 67

摘要

The development of efficient and selective transformations is crucial in synthetic chemistry as it opens new possibilities in the total synthesis of complex molecules. Applying such reactions to the synthesis of ketones is of great importance, as this motif serves as a synthetic handle for the elaboration of numerous organic functionalities. In this context, we report a general and chemoselective method based on an activation/addition sequence ...