Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors

N Khorana, C Smith, K Herrick-Davis…

文献索引：Khorana, Nantaka; Smith, Carol; Herrick-Davis, Kathy; Purohit, Anil; Teitler, Milt; Grella, Brian; Dukat, Malgorzata; Glennon, Richard A. Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3930 - 3937

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被引用次数: 34

摘要

On the basis of an earlier finding that 5-methyl-5 H-1, 2, 3, 4-tetrahydropyrido [4, 3-b] indole (5-methyl-1, 2, 3, 4-tetrahydro-γ-carboline; 1) binds at murine 5-HT5A receptors, preliminary structure-affinity studies were conducted. The present investigation extends these structure- affinity studies using human 5-HT5A receptors and examined additional analogues of 1. It was found (a) that there is little interspecies difference for the affinities of these ...