Resolution of non-proteinogenic amino acids via microbial lipase-catalyzed enantioselective transesterification

T Miyazawa, M Mio, Y Watanabe…

文献索引：Miyazawa, Toshifumi; Mio, Motoe; Watanabe, Yuko; Yamada, Takashi Canadian Journal of Chemistry, 2008 , vol. 86, # 3 p. 219 - 224

全文：HTML全文

被引用次数: 0

摘要

A number of non-proteinogenic amino acids bearing aliphatic side chains were resolved with moderate to good enantioselectivities (E= 15-42) through the Burkholderia cepacia lipase-catalyzed enantioselective transesterification of the 2, 2, 2-trifluoroethyl esters of their N-benzyloxycarbonyl derivatives with methanol as a nucleophile in diisopropyl ether. Key words: non-proteinogenic amino acids, microbial lipases, Burkholderia cepacia lipase, 2, ...