Tetrahedron

Synthesis of suitably protected hydroxymethylene phosphonate-and 'phosphate phosphonate'-analogues of phosphoserine and their incorporation into synthetic …

A Wiemann, R Frank, W Tegge

文献索引：Wiemann, Arndt; Frank, Ronald; Tegge, Werner Tetrahedron, 2000 , vol. 56, # 10 p. 1331 - 1337

全文：HTML全文

被引用次数: 14

摘要

Two suitably protected derivatives of phosphoserine 1 have been prepared in which the regular ester-oxygen is replaced by either a hydroxymethylene moiety or by a phosphorylated hydroxymethylene moiety. The second derivative termed 'phosphate phosphonate'3 yields the hydroxymethylene phosphonate 2 upon enzymatic cleavage of the phosphate. Two peptide sequences containing regular phosphoserine or the new ...