Tetrahedron: Asymmetry

Histidine and deuterium labelled histidine by asymmetric catalytic reduction with gaseous H 2 or D 2; the role of strong non-coordinating acids

E Cesarotti, I Rimoldi, D Zerla, G Aldini

文献索引：Cesarotti; Rimoldi; Zerla; Aldini Tetrahedron Asymmetry, 2008 , vol. 19, # 3 p. 273 - 278

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被引用次数: 5

摘要

An efficient and convenient route for the preparation of natural and unnatural histidine by asymmetric hydrogenation with rhodium–phosphine complexes is described. The reductions were performed in the presence of HBF4 to generate an essential imidazolyl cation. Stereoselective incorporation of D2 in the α, β-positions was obtained by catalytic deuteration in the presence of MeOD.