Synthesis and Antileukemic Activity of Novel 2??(4??(2, 4??dimethoxybenzoyl) phenoxy)??1??(4??(3??(piperidin??4??yl) propyl) piperidin??1??yl) ethanone Derivatives

…, S Chandrappa, SR Ranganatha…

文献索引：Vinaya, Kambappa; Kavitha, Chandagirikoppal V.; Prasanna, Doddakunche S.; Chandrappa, Siddappa; Ranganatha, Somasagara R.; Raghavan, Sathees C.; Rangappa, Kanchugarakoppal S. Chemical Biology and Drug Design, 2012 , vol. 79, # 3 p. 360 - 367

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被引用次数: 1

摘要

A series of novel 2-(4-(2, 4-dimethoxybenzoyl) phenoxy)-1-(4-(3-(piperidin-4-yl) propyl) piperidin-1-yl) ethanone derivatives 9 (a–e) and 10 (a–g) were synthesized and characterized by 1H NMR, IR, mass spectral, and elemental analysis. These novel compounds were evaluated for their antileukemic activity against two human leukemic cell lines (K562 and CEM) by using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5- ...