Organic letters

Synthesis of 4-arylpiperidines from 1-benzyl-4-piperidone: application of the Shapiro reaction and alkenylsilane cross-coupling

C Morrill, NS Mani

文献索引：Morrill, Christie; Mani, Neelakandha S. Organic Letters, 2007 , vol. 9, # 8 p. 1505 - 1508

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被引用次数: 16

摘要

1-Benzyl-3, 4-unsaturated-4-piperidinyl benzyldimethylsilane has been prepared and observed to readily undergo palladium-catalyzed cross-coupling reactions with a variety of aryl iodides and aryl bromides to generate 3, 4-unsaturated 4-arylpiperidines, often at ambient temperature.