Synthesis and Configurational Assignment of the Amino Alcohol in the Eastern Fragment of the GE2270 Antibiotics by Regio-and Stereoselective Addition of 2- …

O Delgado, G Heckmann, HM Müller…

文献索引：Hirao, Akira; Hattori, Iwakazu; Yamaguchi, Kazuo; Nakahama, Seiichi; Yamazaki, Noboru Synthesis, 1982 , # 6 p. 461 - 462

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被引用次数: 38

摘要

... A synthesis of the eastern fragment of the thiazole peptide GE2270 A (1) has been ... the threo-configurated (S,R)-4-bromothiazolyl β-amino alcohol 6 was synthesized from O ... 6-8 This biochemical target, previously unexploited for the clinical development of antibiotics, confers ...