0-Methyl-L-serine* and O-methyl-~-threonine~~~~ are of interest for incorporating into peptides for structure-function relationship studies and in the search for useful analogues of biologically active molecules 0-Methyl-L-threonine is also an antagonist of isoleucine, inhibiting protein synthesis by ascites tumour cells." The N-tert-butyloxycarbonyl (Boc) derivative of 0-methyl-L-serine, which is useful for synthetic work, is best obtained by a five ...