A large number of diamides and diamines were synthesized using 6-amino chrysene and 1- amino pyrene as starting materials. A structure–activity study with cis-platinum as internal control against animal and human tumor lines was carried out in vitro. This study indicated that the in vitro cytotoxicity toward these lines depends on the functionality present in the molecules. The diamino compounds were found to be more potent than the diamides, and ...
