Highly water soluble taxol derivatives: 7-polyethylene glycol carbamates and carbonates

RB Greenwald, A Pendri, D Bolikal

文献索引：Greenwald, Richard; Pendri, Annapurna; Bolikal, Durgadas Journal of Organic Chemistry, 1995 , vol. 60, # 2 p. 331 - 336

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被引用次数: 140

摘要

The first examples of highly water soluble taxol derivatives (0.1 mmol/mL) were prepared by the attachment of polyethylene glycol (molecular weight 2-5 kD) at the 7-position of taxol via a urethane or carbonate linkage. When lower molecular weight polyethylene glycols (350 ...