The Journal of organic chemistry

Solid-phase synthesis of peptidyl thioacids employing a 9-fluorenylmethyl thioester-based linker in conjunction with Boc chemistry

D Crich, K Sana

文献索引：Crich, David; Sana, Kasinath Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7383 - 7388

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被引用次数: 21

摘要

A method for the synthesis of peptidyl thioacids is described on the basis of the use of the N- [9-(thiomethyl)-9 H-fluoren-2-yl] succinamic acid and cross-linked aminomethyl polystyrene resin. The method employs standard Boc chemistry SPPS techniques in conjunction with 9- fluorenylmethyloxycarbonyl protection of side-chain alcohols and amines and 9- fluorenylmethyl protection of side-chain acids and thiols. Cleavage from the resin is ...