Synthesis and Pharmacological Evaluation of Novel Arginine Analogs as Potential Inhibitors of Acetylcholine??Induced Relaxation in Rat Thoracic Aortic Rings
M Jain, MK Barthwal, W Haq, SB Katti…
文献索引：Jain, Manish; Barthwal, Manoj Kumar; Haq, Wahajul; Katti, Seturam B.; Dikshit, Madhu Chemical Biology and Drug Design, 2012 , vol. 79, # 4 p. 459 - 469
It is widely appreciated that the vascular endothelium is capable of modulating vascular smooth muscle tone suiting it well for its role as an important regulator of a number of diverse biological processes. Endothelial dysfunction is an early manifestation of atherothrombosis and a consequence of the established disease. Although several arginine derivatives alkylated at one of the guanidino nitrogen were found to inhibit vasorelaxation ...
