Catalysis letters

L-Valine dipeptide organocatalysts with two amide units for the direct asymmetric aldol reaction in brine

W Huang, H Tian, H Xu, L Zheng, Q Liu, S Zhang

文献索引：Huang, Wenbo; Tian, Hua; Xu, Hao; Zheng, Liangyu; Liu, Qingwen; Zhang, Suoqin Catalysis Letters, 2011 , vol. 141, # 6 p. 872 - 876

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被引用次数: 11

摘要

Abstract A series of valine dipeptide organocatalysts containing a primary amine group and two amide units have been developed and evaluated in the direct asymmetric intermolecular aldol reaction of 4-nitrobenzaldehyde and cyclohexanone. When 2, 4-dinitrophenol (DNP) was used as an acidic additive, the catalyzed reactions of various aldehydes and ketones gave the corresponding aldol products with moderate to high enantioselectivities (up to 95 ...