Straightforward synthesis of chiral silylated amino acids through hydrosilylation

D Marchand, J Martinez…

文献索引：Marchand, Damien; Martinez, Jean; Cavelier, Florine European Journal of Organic Chemistry, 2008 , # 18 p. 3107 - 3112

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被引用次数: 11

摘要

Abstract A method using hydrosilylation of unsaturated amino acids was developed and optimised to obtain silylated amino acids. The platinum (Bu 4 N) 2 PtCl 6 complex was identified as the best catalyst, and the procedure tolerated different unsaturated substrates, silane reagents and protecting groups. Seven silicon-containing α-amino acids were prepared in an enantiomerically pure form under mild conditions in good yields with ...