Bioorganic & medicinal chemistry letters

Design, synthesis, and evaluation of a novel class of 2, 3-disubstituted-tetrahydro-β-carboline derivatives

L Zeng, J Zhang

文献索引：Zeng, Li; Zhang, Jianwei Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3718 - 3722

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被引用次数: 6

摘要

Several novel tetrahydro-β-carboline derivatives with amino acid residues at the 2-position and a glucosamine group at the 3-position of the tetrahydro-β-carboline nucleus were synthesized from a readily available starting material, tryptophane, and were evaluated for their anti-inflammatory activity in the present study. Our results showed that all of the derivatives tested exhibited a significant inhibition of xylene-induced inflammation in mice.