Journal of the American Chemical Society

Enantioselective synthesis of the protein phosphatase inhibitor (-)-motuporin

T Hu, JS Panek

文献索引：Hu, Tao; Panek, James S. Journal of the American Chemical Society, 2002 , vol. 124, # 38 p. 11368 - 11378

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被引用次数: 65

摘要

A highly convergent asymmetric synthesis of the protein phosphatase inhibitor motuporin 1a is described. Synthesis and coupling of the individual peptide fragments [34+ 35→ 51] followed by macrocyclization afforded the fully protected motuporin precursor 33, which is converted to the natural product by dehydration and ester hydrolysis. Six of the eight stereogenic centers associated with the natural product were introduced using asymmetric ...