Synthesis and evaluation of conformationally restricted N-[2-(3, 4-dichlorophenyl) ethyl]-N-methyl-2-(1-pyrrolidinyl) ethylamines at. sigma. receptors. 2. Piperazines, …

…, X He, JTM Linders, C Dominguez, ZQ Gu…

文献索引：Costa, Brian R. de; He, Xiao-shu; Linders, Joannes T.M.; Dominguez, Celia; Gu, Zi Qiang; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 16 p. 2311 - 2320

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被引用次数: 49

摘要

Comparison of the binding data of different N-substituted homologues of 1 with those of the 1-[2-(3, 4-dichlorophenyl) ethyll-4-alkylpiperazines suggests that the two nitrogen atoms of 1 are working in opposition to one another in terms of their sensitivity to steric bulk. The high binding affinity of the 1, 4-diazabicyclo [4.3. 0lnonanes 12 suggests that these may approximate the methyl and pyrrolidine ring conformations found in 1 when it is bound to ...