Antibacterial chalcones––bioisosteric replacement of the 4′-hydroxy group

…, T Boesen, M Larsen, K Schønning, H Kromann

文献索引：Nielsen, Simon Feldbaek; Boesen, Thomas; Larsen, Mogens; Schonning, Kristian; Kromann, Hasse Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 11 p. 3047 - 3054

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被引用次数: 150

摘要

Hydroxy chalcones, for example, Licochalcone A, has for several years been known to be antibacterial. The low aqueous solubility and the medium antibacterial potency have limited the usefulness of the compounds. We describe the bioisosteric replacement of the essential 4′-hydroxy group in the hydroxy chalcones with bioisosters of varied degrees of acidity resulting in both more potent and more soluble compounds. The more acidic 4′-hydroxy ...