The Journal of organic chemistry

Tandem Knoevenagel-Michael addition of aryl sulfonimines with diethyl malonate for synthesis of arylidene dimalonates

R Fan, W Wang, D Pu, J Wu

文献索引：Fan, Renhua; Wang, Weizi; Pu, Dongming; Wu, Jie Journal of Organic Chemistry, 2007 , vol. 72, # 15 p. 5905 - 5907

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被引用次数: 23

摘要

Arylidene dimalonate has the potential to serve as a bone-affinity agent in the treatment of bone disease, 1 and as the precursor for the synthesis of 3-Ar-glutaric acid. 2 Usually it is synthesized in two steps: the Knoevenagel condensation 3 of aromatic aldehydes with malonate or bromomalonate to form arylidene malonate followed by the Michael addition 4 of arylidene malonate with malonate to produce arylidene dimalonate. 5 Mori has reported a tandem Knoevenagel−Michael ...