Nucleophilic aromatic substitution by hydroxide ion under phase-transfer catalysis conditions; fluorine displacement in polyfluorobenzene derivatives

…, D Segal-Lew, M Rabinovitz

文献索引：Feldman, David; Segal-Lew, Drorit; Rabinovitz, Mordecai Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7350 - 7354

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被引用次数: 16

摘要

The traditional synthetic methods for polyfluorophenols include multistage reactions which require the use of dangerous reactants and inconvenient reaction condition~.'~-" A direct nucleophilic aromatic substitution requires solvents such as liquid a" onia, 18 dry pyridine, 19 or tert-butyl alcoholz0 under reflux or high pressure and temperature. 21 The use of ethanolic potassium hydroxide