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Lewis acid mediated reactions of organocopper reagents. A remarkably enhanced regioselective. gamma.-attack of allylic halides and direct alkylation of allylic …

Y Yamamoto, S Yamamoto, H Yatagai…

文献索引:Yamamoto, Yoshinori; Yamamoto, Shinichi; Yatagai, Hidetaka; Maruyama, Kazuhiro Journal of the American Chemical Society, 1980 , vol. 102, # 7 p. 2318 - 2325

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被引用次数: 95

摘要

Abstract: Chemical reactivities and selectivities of a new class of organocopper reagent, RCu-Lewis acid, are described. Regioselective y-attack of allylic halides is realized irrespective of the degree of substitution at the two ends of the allylic sistems, and of the structural factors (cyclic or acyclic) involved. Among the Lewis acids examined, BF3-OEt2 is the most effective with respect to the selectivity and total yield. Propargyl chloride and ...

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