The Journal of Organic Chemistry

Microbiological preparation of (S)-(+)-2, 3-dihydroxy-3-methylbutanoic acid by syn dihydroxylation of 3-methylcrotonic acid

DJ Aberhart

文献索引：Aberhart, D. John Journal of Organic Chemistry, 1980 , vol. 45, # 25 p. 5218 - 5220

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被引用次数: 10

摘要

The substrate,(E)-[4, 4, 4-2H3]-3-methylcrotonic acid, 2b, was synthesized by treatment of methyl tetrolate with lithium dimethyl-& upr rate,^* followed by saponification of the product, 2c. Incubation of 2b as above gave, after methylation, IC showing in the NMR spectrum a