Synthesis of (R)??and (S)??5??(Hydroxymethyl)??3??isopropyloxazolidin??2??one, intermediates in the preparation of optically active β??blockers

…, J Brussee, A van der Gen, CG Kruse

文献索引：Warmerdam; Brussee; Van Der Gen; Kruse Helvetica Chimica Acta, 1994 , vol. 77, # 1 p. 252 - 256

全文：HTML全文

被引用次数: 15

摘要

Abstract The (R)-and (S)-5-(hydroxymethyl)-3-isopropyloxazolidin-2-ones,((R)-and (S)-2, resp.), pivotal intermediates in the preparation of optically active β-blockers, were synthesized using (R, E)-2-hydroxypent-3-enenitrile (1) as the chiral starting material. In the