Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to the nicotinic acetylcholine …

H Nishiwaki, M Kuriyama, H Nagaoka, A Kato…

文献索引：Nishiwaki, Hisashi; Kuriyama, Mituhiro; Nagaoka, Hikaru; Kato, Akira; Yamauchi, Satoshi; Shuto, Yoshihiro; Akamatsu, Miki Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6305 - 6312,8

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被引用次数: 4

摘要

A series of imidacloprid (IMI) derivatives with an alkylated imidazolidine ring were asymmetrically synthesized to evaluate their insecticidal activity against adult female housefly, Musca domestica, and affinity to the nicotinic acetylcholine receptor of the flies. The bulkier the alkyl group, the lower was the receptor affinity, but the derivatives methylated and ethylated at the R-5-position of the imidazolidine ring were equipotent to the ...