Bioorganic & medicinal chemistry letters

Novel hexacyclic camptothecin derivatives. Part 1: Synthesis and cytotoxicity of camptothecins with an A-ring fused 1, 3-oxazine ring

S Wang, Y Li, Y Liu, A Lu, Q You

文献索引：Wang, Sheng; Li, Yuyan; Liu, Yonghui; Lu, Aijun; You, Qidong Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4095 - 4097

全文：HTML全文

被引用次数: 47

摘要

A novel series of A-ring modified hexacyclic camptothecin derivatives containing a 1, 3- oxazine ring were first designed and synthesized. All of the hexacyclic camptothecins were assayed for in vitro cytotoxicity against nine human cancer cell lines. Among these compounds, 9b and 9c showed most potent cytotoxicity against several cell lines. Particularly, 9c was about 13-fold more potent than camptothecin, and about sixfold more ...