Tetrahedron letters

Kinetic resolution of ketone cyanohydrin acetates with a microbial enzyme

H Ohta, Y Kimura, Y Sugano

文献索引：Ohta, Hiromichi; Kimura,Yoichi; Sugano, Yasushi Tetrahedron Letters, 1988 , vol. 29, # 52 p. 6957 - 6960

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被引用次数: 26

摘要

Incubation of d1-1-cyano-1-methylalkyl (or alkenyl) acetates (methyl ketone cyanohydrin acetates) with cells of IAM 4682 afforded optically active acetates and the corresponding ketones via asymmetric hydrolysis. Resulting (S)-2-cyano-2-undecyl acetate was converted to the aminofuranone derivative without losing its optical purity. ... Optically active ketone cyanohydrin acetates have been prepared via microbial hydrolysis. ... Addition of 0.5 eq. of the chiral shift reagent to ...