The Journal of Organic Chemistry

A mild two-step method for the hydrolysis of lactams and secondary amides

DL Flynn, RE Zelle, PA Grieco

文献索引：Flynn, Daniel L.; Zelle, Robert E.; Grieco, Paul A. Journal of Organic Chemistry, 1983 , vol. 48, # 14 p. 2424 - 2426

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被引用次数: 298

摘要

has been shown by Mackay and Shepherd that the cyclization product is an inhibitor of histidine decarboxylase." In reversed micelles, the rate of cyclization was also appreciably affected by the water content (Figure 1). The apparent pseudo-first-order rate constant kobd consists of the formation constant for the Schiff base, K, and the specific rate constant for the cyclization, k,(eq 1). The K value of Schiff base formation between pyri-K [histidine]= kCK [ ...