Bioorganic & medicinal chemistry

Hippuryl-α-methylphenylalanine and hippuryl-α-methylphenyllactic acid as substrates for carboxypeptidase A. Syntheses, kinetic evaluation and mechanistic …

M Lee, DH Kim

文献索引：Lee, Mijoon; Kim, Dong H. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 4 p. 815 - 823

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被引用次数: 22

摘要

(R)-and (S)-Hippuryl-α-methylphenylalanine [(R)-and (S)-Hipp-α-MePhe] and (S)-hippuryl-α- methylphenyllactic acid [(S)-Hipp-α-MeOPhe] were synthesized and evaluated as substrates for carboxypeptidase A (CPA) in an effort to shed further light on the catalytic mechanism of