Regio-and enantioselective catalytic epoxidation of conjugated polyenes. Formal synthesis of LTA4 methyl ester

S Chang, NH Lee, EN Jacobsen

文献索引：Chang, Sukbok; Lee, Nam Ho; Jacobsen, Eric N. Journal of Organic Chemistry, 1993 , vol. 58, # 25 p. 6939 - 6941

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被引用次数: 97

摘要

Sukbok Chang,l Nam Ho Lee,2 and Eric N. Jac0bsen.J ... Department of Chemistry, University of Illinois, Urbana, Illinois 61801, and Department of Chemistry, Harvard University, Cambridge, Massachusetts 02139 ... Summary: The (salen)Mn(III)-catalyzed asymmetric ep- oxidation reaction exhibits regioselectivity for attack at cis double bonds of conjugated dienes to afford enanti- omerically enriched trans-vinyl epoxides as the major products.