Synthesis of 2-aryl-3, 3, 3-trifluoropropanoic acids using electrochemical carboxylation of (1-bromo-2, 2, 2-trifluoroethyl) arenes and its application to the synthesis of β …
Electrochemical carboxylation of (1-bromo-2, 2, 2-trifluoroethyl) arenes resulted in an efficient fixation of carbon dioxide to give the corresponding 2-aryl-3, 3, 3-trifluoropropanoic acids in good yields, and the present reactions were successfully applied to the synthesis of β, β, β-trifluorinated non-steroidal anti-inflammatory drugs (NSAIDs).
