First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids
E Chosson, C Rochais, R Legay, JS de Oliveira Santos…
文献索引：Chosson, Elizabeth; Rochais, Christophe; Legay, Remi; Santos, Jana Sopkova De Oliveira; Rault, Sylvain; Dallemagne, Patrick Tetrahedron, 2011 , vol. 67, # 14 p. 2548 - 2554
Recently, hydroarylation of cinnamic acids 1 was reported as an efficient method to synthesize benzhydrylacetic acid derivatives. 1 Using phenol, this reaction was also widely used for the synthesis of dihydrocoumarin derivatives 2 with potential biological interest (Scheme 1). 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 and 13 However, such hydroarylations need highly acidic media and are generally limited to electron-rich starting materials. It was however very recently ...
