Tetrahedron Letters

Convenient synthesis of protected primary amines from nitriles

S Caddick, AKK Haynes, DB Judd, MRV Williams

文献索引：Caddick, Stephen; De K. Haynes, Alexandra K.; Judd, Duncan B.; Williams, Meredith R.V. Tetrahedron Letters, 2000 , vol. 41, # 18 p. 3513 - 3516

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被引用次数: 61

摘要

Investigations into the use of nickel chloride and sodium borohydride for the reduction of nitriles showed the secondary amine dimers to be the major products under normal conditions. The addition of a suitable trapping agent, such as di-tert-butyl dicarbonate, allowed the isolation of the protected primary amines.