Neuroleptic activity in 5-aryltetrahydro-. gamma.-carbolines

…, JJ Plattner, WM Welch, A Weissman…

文献索引：Harbert, Charles A.; Plattner, Jacob J.; Welch, Willard M.; Weissman, Albert; Koe, B. Kenneth Journal of Medicinal Chemistry, 1980 , vol. 23, # 6 p. 635 - 643

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被引用次数: 69

摘要

Since the discovery of chlorpromazine as an effective antipsychotic agent, large numbers of potential neuroleptics have been synthesized. Despite this intense research activity, there are still relatively few structurally distinct classes of antipsychotic drugs which have confirmed clinical activity.'One of the largest classes by far is the linear tricyclic series characterized by 6, 6, 6 or 6, 7, 6 fused ring systems with an amine-containing side chain ...