Tetrahedron

Isolation and total synthesis of gymnastatin N, a POLO-like kinase 1 active constituent from the fungus Arachniotus punctatus

CW Phoon, B Somanadhan, SCH Heng, A Ngo, SB Ng…

文献索引：Phoon, Chee Wee; Somanadhan, Brinda; Heng, Sabrina Cher Hui; Ngo, Anna; Ng, Siew Bee; Butler, Mark S.; Buss, Antony D.; Sim, Mui Mui Tetrahedron, 2004 , vol. 60, # 50 p. 11619 - 11628

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被引用次数: 13

摘要

A high throughput screen against POLO-like kinase 1 (Plk1), an anti-cancer target, identified an active extract from the fungus Arachniotus punctatus. Bioassay guided fractionation led to the isolation of the new natural product, gymnastatin N () and the known compound aranorosinol A () with IC50 values of 13 and 118μM, respectively. A 12′-hydroxy analog of gymnastatin N,, was also isolated as a minor component. Gymnastatin N () was found to ...