Development of 6-benzyl substituted 4-aminocarbonyl-1, 4-diazepane-2, 5-diones as orally active human chymase inhibitors

…, S Imajo, Y Tomimori, Y Fukuda, T Nakatsuka

文献索引：Maruoka, Hiroshi; Muto, Tsuyoshi; Tanaka, Taisaku; Imajo, Seiichi; Tomimori, Yoshiaki; Fukuda, Yoshiaki; Nakatsuka, Takashi Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3435 - 3439

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被引用次数: 15

摘要

A novel series of 6-benzyl substituted 4-aminocarbonyl-1, 4-diazepane-2, 5-diones was designed, synthesized, and evaluated as human chymase inhibitors. From this series, we identified several compounds which were effective, via oral administration, in a mouse model of chronic dermatitis.