Complexation and conjugation approaches to evaluate siRNA delivery using cationic, hydrophobic and amphiphilic peptides

JW Park, EK Bang, EM Jeon, BH Kim

文献索引：Park, Jung Woo; Bang, Eun-Kyoung; Jeon, Eun Mi; Kim, Byeang Hyean Organic and Biomolecular Chemistry, 2012 , vol. 10, # 1 p. 96 - 102

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被引用次数: 3

摘要

In this study, we used solid phase synthesis to prepare three kinds of peptides and then formulated their peptide–siRNA complexes and peptide–siRNA conjugates. Both the complexation and conjugation systems were nontoxic and allowed the delivery of siRNA into the cytoplasm without the need for any transfection agents and with subsequent inhibition of gene expression.