Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: An easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 …
E Rasolofonjatovo, O Provot, A Hamze, J Bignon…
文献索引：Rasolofonjatovo, Evelia; Provot, Olivier; Hamze, Abdallah; Bignon, Jerome; Thoret, Sylviane; Brion, Jean-Daniel; Alami, Mouad European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3617 - 3626
A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented.
