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Use of an iridium-catalyzed redox-neutral alcohol-amine coupling on kilogram scale for the synthesis of a GlyT1 inhibitor

MA Berliner, SPA Dubant, T Makowski…

文献索引:Org. Process Res. Dev., , vol. 15, # 5 p. 1052 - 1062

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被引用次数: 42

摘要

... Org. ... the Corey–Kim,(11) Parikh–Doering,(12) and Swern(13) oxidations were most robust for gram-scale reactions.(14) Of these, Swern and Parikh–Doering processes provided the ... Unfortunately, this process proved only partially successful when executed on scale (1.5 kg). ...

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